Article
Roles of the crp and sipB genes of Salmonella enterica serovar Typhimurium in protective efficacy and immune responses to vaccination in mice.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire - 1 Apr 2018
Chen Songbiao, Liao Chengshui, Zhang Chunjie, Cheng Xiangchao
Abstract excerpt
Salmonella enterica serovar Typhimurium has a wide host range and is capable of causing infections ranging from severe gastroenteritis to systemic infection in humans. To determine if attenuated S. Typhimurium strains can serve as safe and effective oral vaccines to prevent typhoid fever, the biologic characteristics of crp and sipB deletion mutants were evaluated. Previous studies had found that the crp and sipB...
Topics
- Animals
- Antibodies, Bacterial
- Bacterial Proteins
- HeLa Cells
- Humans
- Mice
- Mice, Inbred BALB C
- Mutation
- Salmonella Infections, Animal
- Salmonella Vaccines