Article
Infection with an avirulent phoP mutant of Neisseria meningitidis confers broad cross-reactive immunity.
Infection and immunity - 1 Jan 2004
Newcombe J, Eales-Reynolds L-J, Wootton L, Gorringe A R, Funnell S G P, Taylor S C, McFadden J J
Abstract excerpt
Successful vaccines against serogroup A and C meningococcal strains have been developed, but current serogroup B vaccines provide protection against only a limited range of strains. The ideal meningococcal vaccine would provide cross-reactive immunity against the variety of strains that may be encountered in any community, but it is unclear whether the meningococcus possesses immune targets that have the...
Topics
- Animals
- Antibodies, Bacterial
- Bacterial Proteins
- Blood Bactericidal Activity
- Cell Line
- Cross Reactions
- Gene Expression Regulation, Bacterial
- Humans
- Meningococcal Infections
- Mice
- Mutation
- Neisseria meningitidis
- Opsonin Proteins
- Phagocytosis