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Article

Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes.

The Journal of biological chemistry - 9 Apr 2004

Stoeckman Angela K, Ma Lin, Towle Howard C

Abstract excerpt

The expression of genes encoding enzymes involved in de novo triglyceride synthesis (lipogenesis) is transcriptionally induced in the liver in response to increased glucose metabolism. The carbohydrate response element-binding protein (ChREBP) is a newly identified basic helix-loop-helix/leucine zipper transcription factor proposed to regulate the expression of the glucose-responsive gene pyruvate kinase. This...

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Identifiers

PMID: 14742444
DOI: 10.1074/jbc.M311301200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes.PMID 14742444Read ↗

The role of O-linked GlcNAc modification on the glucose response of ChREBP.Semantic proximity Read ↗

Identification and function of phosphorylation in the glucose-regulated transcription factor ChREBP.Semantic proximity Read ↗

Integrated Expression Profiling and Genome-Wide Analysis of ChREBP Targets Reveals the Dual Role for ChREBP in Glucose-Regulated Gene ExpressionSemantic proximity Read ↗

Carbohydrate regulation of hepatic gene expression. Evidence against a role for the upstream stimulatory factor.Semantic proximity Read ↗

Hepatic Elovl6 gene expression is regulated by the synergistic action of ChREBP and SREBP-1c.Semantic proximity Read ↗

Casein kinase II increases the transcriptional activities of MRF4 and MyoD independently of their direct phosphorylation.Semantic proximity Read ↗

Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activity.Semantic proximity Read ↗

Carbohydrate Response Element Binding Protein Gene Expression Is Positively Regulated by Thyroid HormoneSemantic proximity Read ↗

ChREBP Rather than SHP Regulates Hepatic VLDL SecretionSemantic proximity Read ↗

Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: discovery of a new leucine-rich nuclear export signal site.Semantic proximity Read ↗

A mutation in the peroxisome proliferator-activated receptor gamma-binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in mice.Semantic proximity Read ↗

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