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Article

Hepatic Elovl6 gene expression is regulated by the synergistic action of ChREBP and SREBP-1c.

Biochemical and biophysical research communications - 23 Sept 2016

Bae Jin-Sik, Oh Ah-Reum, Lee Ho-Jae, Ahn Yong-Ho, Cha Ji-Young

Abstract excerpt

Elongation of very long chain fatty acids protein 6 (ELOVL6), a rate-limiting enzyme for the elongation of saturated and monounsaturated fatty acids with 12, 14, and 16 carbons, plays a key role in energy metabolism and insulin sensitivity. Hepatic Elovl6 expression is upregulated in the fasting-refeeding response and in leptin-deficient ob/ob mice. Mouse Elovl6 has been shown to be a direct target of sterol...

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Source

Identifiers

PMID: 27524233
DOI: 10.1016/j.bbrc.2016.08.061

Genes

ELOVL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hepatic Elovl6 gene expression is regulated by the synergistic action of ChREBP and SREBP-1c.PMID 27524233Read ↗

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Identification of human ELOVL5 enhancer regions controlled by SREBP.Semantic proximity Read ↗

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HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasisSemantic proximity Read ↗

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Integration of metabolomic and transcriptomic analyses reveals regulatory functions of the ChREBP transcription factor in energy metabolismSemantic proximity Read ↗

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