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Article

Carbohydrate regulation of hepatic gene expression. Evidence against a role for the upstream stimulatory factor.

The Journal of biological chemistry - 14 Mar 1997

Kaytor E N, Shih H, Towle H C

Abstract excerpt

Hepatic expression of the genes encoding L-type pyruvate kinase (L-PK) and S14 is induced in rats upon feeding them a high carbohydrate, low fat diet. A carbohydrate response element (ChoRE) containing two CACGTG-type E boxes has been mapped in the 5'-flanking region of both of these genes. The n...

Topics

Animals
Carbohydrate Metabolism
Carbohydrates
DNA-Binding Proteins
Gene Expression Regulation
Liver
Male
Mutation
Rats
Rats, Sprague-Dawley
Transcription Factors
Transcription, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Upstream Stimulatory Factors

Source

Identifiers

PMID: 9054457
DOI: 10.1074/jbc.272.11.7525

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9054457-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Carbohydrate regulation of hepatic gene expression. Evidence against a role for the upstream stimulatory factor.PMID 9054457Read ↗

An indirect role for upstream stimulatory factor in glucose-mediated induction of pyruvate kinase and S14 gene expression.Semantic proximity Read ↗

MECHANISMS BY WHICH CARBOHYDRATES REGULATE EXPRESSION OF GENES FOR GLYCOLYTIC AND LIPOGENIC ENZYMESSemantic proximity Read ↗

Spot 14 protein interacts and co-operates with chicken ovalbumin upstream promoter-transcription factor 1 in the transcription of the L-type pyruvate kinase gene through a specificity protein 1 (Sp1) binding site.Semantic proximity Read ↗

Upstream stimulatory factor proteins are major components of the glucose response complex of the L-type pyruvate kinase gene promoter.Semantic proximity Read ↗

Multiple E-boxes in the distal promoter of the rat pyruvate carboxylase gene function as a glucose-responsive element.Semantic proximity Read ↗

Integration of metabolomic and transcriptomic analyses reveals regulatory functions of the ChREBP transcription factor in energy metabolismSemantic proximity Read ↗

The role of O-linked GlcNAc modification on the glucose response of ChREBP.Semantic proximity Read ↗

Identification and function of phosphorylation in the glucose-regulated transcription factor ChREBP.Semantic proximity Read ↗

Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes.Semantic proximity Read ↗

Glucose Regulation of Gene TranscriptionSemantic proximity Read ↗

Transcriptional regulation of adipocyte hormone-sensitive lipase by glucose.Semantic proximity Read ↗

SREBP-1 Interacts with Hepatocyte Nuclear Factor-4α and Interferes with PGC-1 Recruitment to Suppress Hepatic Gluconeogenic GenesSemantic proximity Read ↗

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