Article
A mutation in the peroxisome proliferator-activated receptor gamma-binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in mice.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jan 2002
Olswang Yael, Cohen Hannah, Papo Orit, Cassuto Hanoch, Croniger Colleen M, Hakimi Parvin, Tilghman Shirley M, Hanson Richard W, Reshef Lea
Abstract excerpt
Regulation of the turnover of triglycerides in adipose tissue requires the continuous provision of 3-glycerophosphate, which may be supplied by the metabolism of glucose or by glyceroneogenesis, the de novo synthesis of 3-glycerophosphate from sources other than hexoses or glycerol. The importance of glyceroneogenesis in adipose tissue was assessed in mice by specifically eliminating the expression of the...
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