Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An interleukin-6 promoter variant is not associated with an increased risk for Alzheimer's disease.

Dementia and geriatric cognitive disorders - 1 Jan 2004

Depboylu Candan, Lohmüller Frank, Gocke Petra, Du Yansheng, Zimmer Reinhilde, Gasser Thomas, Klockgether Thomas, Dodel Richard C

Abstract excerpt

Recent studies have implicated interleukin-6 (IL-6) in the pathogenesis of Alzheimer's disease (AD). Neuro-inflammatory processes surrounding the amyloid plaques contribute to the progression of AD-related neurodegeneration. IL-6 is a multifunctional inflammatory cytokine which possibly acts as a mediator in the local immune response in the brain of AD patients. In this study we investigated whether the risk of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Apolipoproteins E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Heterozygote

Share to Interleukin-6

Share to Point Mutation

Share to Polymorphism, Restriction Fragment Length

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 14739540
DOI: 10.1159/000076352

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An interleukin-6 promoter variant is not associated with an increased risk for Alzheimer's disease.PMID 14739540Read ↗

Interleukin 6-174 G/C promoter and variable number of tandem repeats (VNTR) gene polymorphisms in sporadic Alzheimer's disease.Semantic proximity Read ↗

Interleukin-6 gene (-174 C/G ) and apolipoprotein E gene polymorphisms and the risk of Alzheimer disease in a Polish population.Semantic proximity Read ↗

Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain.Semantic proximity Read ↗

Polymorphism 174 G/C of interleukin 6 gene in Alzheimer's disease--preliminary report.Semantic proximity Read ↗

Interleukin 6-174 G/C promoter gene polymorphism and sporadic Alzheimer's disease: geographic allele and genotype variations in Europe.Semantic proximity Read ↗

The -174 G/C polymorphism of the interleukin-6 gene promoter is associated with Alzheimer's disease in an Italian population [corrected].Semantic proximity Read ↗

A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease.Semantic proximity Read ↗

Interleukin-6 -174G/C polymorphism and the risk of Alzheimer's disease in Caucasians: a meta-analysis.Semantic proximity Read ↗

Association between an interleukin-6 promoter and 3' flanking region haplotype and reduced Alzheimer's disease risk in a German population.Semantic proximity Read ↗

Association between polymorphism in the promoter region of Interleukin 6 (-174 G/C) and risk of Alzheimer's disease: a meta-analysis.Semantic proximity Read ↗

Association between interleukin 6 gene haplotype and Alzheimer's disease: a Brazilian case-control study.Semantic proximity Read ↗

Interleukin‐6–174 G/C Promoter Gene Polymorphism C Allele Reduces Alzheimer's Disease RiskSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.