Article
Interleukin-6 gene (-174 C/G ) and apolipoprotein E gene polymorphisms and the risk of Alzheimer disease in a Polish population.
Neurologia i neurochirurgia polska - 1 Jan 2000
Klimkowicz-Mrowiec Aleksandra, Wołkow Paweł, Spisak Karolina, Maruszak Aleksandra, Styczyńska Maria, Barcikowska Maria, Szczudlik Andrzej, Słowik Agnieszka
Abstract excerpt
BACKGROUND AND PURPOSE: Inflammation plays a prominent role in Alzheimer disease (AD) pathogenesis. Interleukin-6 (IL-6), a pro-inflammatory cytokine, and some genetic variations in the IL-6 gene have been reported to be associated with a risk of AD. However, the results of the conducted studies are equivocal. MATERIAL AND METHODS: We genotyped IL-6 (-174 C/G) and apolipoprotein E gene (APOE) common polymorphisms...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.