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Article

Interleukin‐6–174 G/C Promoter Gene Polymorphism C Allele Reduces Alzheimer's Disease Risk

26 Mar 2003

Abstract excerpt

To the Editor: Alzheimer's disease (AD) pathophysiology encompasses a variety of neurodegenerative, inflammatory, metabolic, and genetic aspects. The cytokine interleukin-6 (IL-6) is reported to play a role in AD pathogenesis1-3 and neurodegeneration.3-5 In the IL-6 gene, a G/C (genotype) polymorphism in the promoter at position –174 (prom) is associated with altered IL-6 transcription rates.6 A variable number...

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PMID: 12657090
DOI: 10.1046/j.1532-5415.2003.51177.x

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