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Article

Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain.

Neurobiology of aging - 1 Nov 2003

Licastro Federico, Grimaldi Luigi Maria Edoardo, Bonafè Massimiliano, Martina Chiappelli, Olivieri Fabiola, Cavallone Luca, Giovanietti Simona, Masliah Eliezer, Franceschi Claudio

Abstract excerpt

Two different polymorphic regions of the interleukin-6 (IL-6) gene were investigated in patients with Alzheimer's disease (AD) and non-demented controls. The -174 C allele in the promoter region of IL-6 gene was over-represented in AD patients compared to controls and significantly increased the risk of AD. Moreover, the -174 CC genotype was associated with a high risk of the disease in women. The D allele of a...

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PMID: 12928051
DOI: 10.1016/s0197-4580(03)00013-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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