Article
Interleukin 6-174 G/C promoter and variable number of tandem repeats (VNTR) gene polymorphisms in sporadic Alzheimer's disease.
Progress in neuro-psychopharmacology & biological psychiatry - 1 Feb 2010
Capurso Cristiano, Solfrizzi Vincenzo, Colacicco Anna Maria, D'Introno Alessia, Frisardi Vincenza, Imbimbo Bruno P, Lorusso Maria, Vendemiale Gianluigi, Denitto Marta, Santamato Andrea, Seripa Davide, Pilotto Alberto, Fiore Pietro, Capurso Antonio, Panza Francesco
Abstract excerpt
BACKGROUND: Previous studies examining the association between the interleukin 6 (IL-6)-174 C/G polymorphism and Alzheimer's disease (AD) have yielded conflicting results. Furthermore, the C allele of the IL-6 variable number of tandem repeats (VNTR) polymorphism was associated with a delayed onset and a decreased risk of AD. METHODS: A total sample of 149 AD patients, and 298 age- and sex-matched unrelated...
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