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Article

Frequent germline mutation in the BRCA2 gene in esophageal squamous cell carcinoma patients from a low-risk Chinese population.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2011

Zhong Lei, Zhu Zhong-Zheng, Shen Yanying, Sun Guangyuan, Zhao Xuewei, Zhang Shirong, Yin Xiaolu, Zhu Jianshan, Xu Zhifei, Zhu Guanshan

Abstract excerpt

BACKGROUND: The incidence of esophageal squamous cell cancer (ESCC) is strikingly variable by geographic area, which reflect different exposures to risk factors, including genetic predisposition. Previous studies of ESCC patients from several high-risk populations suggested that BRCA2 might play a role in the etiology. This study was conducted to screen for mutations of BRCA2 gene in ESCC cases from a low-risk...

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Identifiers

PMID: 22126563

Genes

BRCA2

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