Article
Regulatory analysis of the mouse Fgf3 gene: control of embryonic expression patterns and dependence upon sonic hedgehog (Shh) signalling.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 May 2004
Powles Nicola, Marshall Heather, Economou Androulla, Chiang Chin, Murakami Akira, Dickson Clive, Krumlauf Robb, Maconochie Mark
Abstract excerpt
Fgf3 displays a dynamic and complex expression pattern during mouse embryogenesis. To address the molecular mechanisms underlying Fgf3 expression, we used a transgenic approach to assay genomic regions from the mouse Fgf3 gene for regulatory activity. We identified an enhancer that mediates major components of embryonic expression, governing expression in the midbrain, hindbrain, surface ectoderm, dorsal roots...
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