Article
CK1 and GSK3 in the Drosophila and mammalian circadian clock.
Novartis Foundation symposium - 1 Jan 2003
Harms Emily, Young Michael W, Saez Lino
Abstract excerpt
Two kinases, DOUBLETIME and SHAGGY, have been shown to play a role in the circadian clock. DOUBLETIME, the Drosophila orthologue of casein kinase 1, can phosphorylate PERIOD in the cytoplasm and in the nucleus. This phosphorylation destabilizes PERIOD in both locations and sets patterns of both c...
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