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Article

BAFF overexpression and accelerated glomerular disease in mice with an incomplete genetic predisposition to systemic lupus erythematosus.

Arthritis and rheumatism - 1 Jul 2005

Stohl William, Xu Dong, Kim Kyoung Soo, Koss Michael N, Jorgensen Trine N, Deocharan Bisram, Metzger Troy E, Bixler Sarah A, Hong Yeon Sik, Ambrose Christine M, Mackay Fabienne, Morel Laurence, Putterman Chaim, Kotzin Brian L, Kalled Susan L

Abstract excerpt

OBJECTIVE: To determine whether overexpression of BAFF can accelerate the development of systemic lupus erythematosus-associated end-organ disease in hosts with an underlying autoimmune diathesis. METHODS: We introduced a BAFF transgene (Tg) into autoimmune-prone B6.Sle1 and B6.Nba2 mice and evaluated these mice for serologic autoimmunity and renal pathology. RESULTS: B6.Sle1.BAFF and B6.Nba2.BAFF mice, but not...

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Identifiers

PMID: 15986357
DOI: 10.1002/art.21138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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