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Article

TNFR-associated factor 2 deficiency in B lymphocytes predisposes to chronic lymphocytic leukemia/small lymphocytic lymphoma in mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2012

Pérez-Chacón Gema, Llobet David, Pardo Constanza, Pindado José, Choi Yongwon, Reed John C, Zapata Juan M

Abstract excerpt

We have previously shown that transgenic (tg) mice expressing in B lymphocytes both BCL-2 and a TNFR-associated factor 2 (TRAF2) mutant lacking the really interesting new gene and zinc finger domains (TRAF2DN) develop small lymphocytic lymphoma and chronic lymphocytic leukemia with high incidence (Zapata et al. 2004. Proc. Nat. Acad. Sci. USA 101: 16600-16605). Further analysis of the expression of TRAF2 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Lymphoma, Follicular

Share to Mice, Transgenic

Share to Protein Structure, Tertiary

Share to TNF Receptor-Associated Factor 2

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Source

Open in PubMed Open full text

Identifiers

PMID: 22711886
DOI: 10.4049/jimmunol.1200814
PMCID: PMC3526975

Genes

TRAF2
BCR
TRAF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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