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Article

Global T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFF-independent, systemic lupus erythematosus-like autoimmunity.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2008

Stohl William, Jacob Noam, Quinn William J, Cancro Michael P, Gao Huaxin, Putterman Chaim, Gao Xiaoni, Pricop Luminita, Koss Michael N

Abstract excerpt

In otherwise non-autoimmune-prone C57BL/6 (B6) mice rendered genetically deficient in CD152 (CTLA-4), polyclonal hypergammaglobulinemia with increased levels of systemic lupus erythematosus (SLE)-associated IgG autoantibodies, glomerular IgG and C3 deposition, and interstitial nephritis all developed by 3-5 wk of age. Remarkably, superimposing genetic deficiency of BAFF (B cell-activating factor belonging to the...

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Identifiers

PMID: 18566449
DOI: 10.4049/jimmunol.181.1.833
PMCID: PMC2587218

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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