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Article

Epigenetic cell fate regulation of hepatic stellate cells

19 Apr 2011

Abstract excerpt

Research in the past three decades has identified key mediators and signaling mechanisms responsible for myofibroblastic transdifferentiation (MTD) of hepatic stellate cells (HSC), the pivotal event in liver fibrogenesis. Yet, fundamental understanding of the MTD from the viewpoint of cell fate or lineage regulation has been elusive. Recent studies using genetic cell fate mapping techniques demonstrate HSC are...

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PMID: 21504520
DOI: 10.1111/j.1872-034x.2011.00804.x

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