Article
Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer.
Molecular and cellular biology - 1 Mar 1992
Goyette M C, Cho K, Fasching C L, Levy D B, Kinzler K W, Paraskeva C, Vogelstein B, Stanbridge E J
Abstract excerpt
Carcinogenesis is a multistage process that has been characterized both by the activation of cellular oncogenes and by the loss of function of tumor suppressor genes. Colorectal cancer has been associated with the activation of ras oncogenes and with the deletion of multiple chromosomal regions i...
Topics
- Alleles
- Base Sequence
- Chromosomes, Human, Pair 15
- Chromosomes, Human, Pair 17
- Chromosomes, Human, Pair 18
- Chromosomes, Human, Pair 5
- Colorectal Neoplasms
- DNA, Neoplasm
- Genes, Tumor Suppressor
- Humans