Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential activation of mitogen-activated protein kinases in ischemic and anesthetic preconditioning.

Anesthesiology - 1 Jan 2004

da Silva Rafaela, Grampp Thomas, Pasch Thomas, Schaub Marcus C, Zaugg Michael

Abstract excerpt

BACKGROUND: Accumulating evidence pinpoints to the pivotal role of mitogen-activated protein kinases (MAPKs) in the signal transduction underlying cardiac preconditioning. METHODS: PD98059, an inhibitor of extracellular signal-regulated protein kinase (MEK-ERK1/2), and SB203580, an inhibitor of p38 MAPK, were used to evaluate the role of MAPKs with respect to postischemic functional recovery in isolated perfused...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anesthetics
Share to Heart
Share to Mitogen-Activated Protein Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinase 3

Share to Mitogen-Activated Protein Kinases

Share to p38 Mitogen-Activated Protein Kinases

Share to Rats, Wistar

Share to Reperfusion Injury

Source

Identifiers

PMID: 14695725
DOI: 10.1097/00000542-200401000-00013

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential activation of mitogen-activated protein kinases in ischemic and anesthetic preconditioning.PMID 14695725Read ↗

Effect of p38 MAP kinases on contractility and ischemic injury in intact heart.Semantic proximity Read ↗

p38 alpha mitogen-activated protein kinase inhibition improves cardiac function and reduces myocardial damage in isoproterenol-induced acute myocardial injury in rats.Semantic proximity Read ↗

Microarray expression analysis in delayed cardioprotection: the effect of exercise, AICAR, or metformin and the possible role of AMP-activated protein kinase (AMPK).Semantic proximity Read ↗

CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury.Semantic proximity Read ↗

The activation of p38 alpha, and not p38 beta, mitogen-activated protein kinase is required for ischemic preconditioning.Semantic proximity Read ↗

Ischemic but not pharmacological preconditioning elicits a gene expression profile similar to unprotected myocardium.Semantic proximity Read ↗

The Cardioprotective Effects of Late-Phase Remote Preconditioning of Trauma Depends on Neurogenic Pathways and the Activation of PKC and NF-κB (But Not iNOS) in Mice.Semantic proximity Read ↗

Deficiency in TLR4 signal transduction ameliorates cardiac injury and cardiomyocyte contractile dysfunction during ischemia.Semantic proximity Read ↗

Inhibition of iNOS protects the aging heart against beta-adrenergic receptor stimulation-induced cardiac dysfunction and myocardial ischemic injury.Semantic proximity Read ↗

Ischaemic postconditioning protects isolated mouse hearts against ischaemia/reperfusion injury via sphingosine kinase isoform-1 activation.Semantic proximity Read ↗

A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury.Semantic proximity Read ↗

Hepatic preconditioning using lipopolysaccharide: association with specific negative regulators of the Toll-like receptor 4 signaling pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.