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Article

A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury.

Cardiovascular research - 1 Oct 2007

Jin Zhu-Qiu, Zhang Jianqing, Huang Yong, Hoover Holly E, Vessey Donald A, Karliner Joel S

Abstract excerpt

OBJECTIVE: Sphingosine kinase (SphK) is a key enzyme in the synthesis of sphingosine 1-phosphate (S1P), a bioactive sphingolipid. SphK is involved in ischemic preconditioning (IPC). To date no studies in genetically altered animals have examined the role of SphK1 in myocardial ischemia/reperfusion (IR) injury and IPC. METHODS AND RESULTS: Wild-type and SphK1 null mouse hearts were subjected to IR (50 min global...

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Identifiers

PMID: 17610857
DOI: 10.1016/j.cardiores.2007.05.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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