Article
Effect of p38 MAP kinases on contractility and ischemic injury in intact heart.
Acta physiologica Hungarica - 1 Sept 2009
Cross H R, Li M, Petrich B G, Murphy E, Wang Y, Steenbergen Charles
Abstract excerpt
The p38 MAP kinases are stress-activated MAP kinases whose induction is often associated with the onset of heart failure. This study investigated the role of p38 MAP kinase isoforms in the regulation of myocardial contractility and ischemia/reperfusion injury using mice with cardiac-specific expression of kinase dead (dominant negative) mutants of p38alpha (p38alphadn) or p38beta (p38betadn). Hearts were...
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