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Article

p38 alpha mitogen-activated protein kinase inhibition improves cardiac function and reduces myocardial damage in isoproterenol-induced acute myocardial injury in rats.

Journal of cardiovascular pharmacology - 1 Oct 2004

Li Zhihe, Tran Thomas-Toan, Ma Jing Ying, O'Young Gilbert, Kapoun Ann M, Chakravarty Sarvajit, Dugar Sundeep, Schreiner George, Protter Andrew A

Abstract excerpt

p38 mitogen-activated protein (MAP) kinase is activated during ischemic/hypoxic myocardial injury. However, the role of activated p38 MAP kinase on cardiac function after myocardial injury is not well understood. In the present study, we investigated the cardioprotective effects of p38 MAP kinase inhibition in a rat model of acute myocardial injury, induced by subcutaneous injection of isoproterenol (ISO, 20...

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Identifiers

PMID: 15454858
DOI: 10.1097/01.fjc.0000141474.06383.6f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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