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Article

Frequent loss of heterozygosity targeting the inactive X chromosome in melanoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2003

Indsto James O, Nassif Najah T, Kefford Richard F, Mann Graham J

Abstract excerpt

After previous preliminary observations of paradoxical deletion events affecting the inactive X chromosome in melanoma, we have surveyed the X chromosome for deletions using 23 polymorphic microsatellite markers in 28 informative (female XX) metastatic melanomas. Ten tumors (36%) showed at least one loss of heterozygosity (LOH) event, and in two cases an entire chromosome showed LOH at all informative loci. Four...

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PMID: 14695151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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