Article
Identification of two distinct deletion targets at 11q23 in cutaneous malignant melanoma.
International journal of cancer - 18 Jan 1999
Herbst R A, Gutzmer R, Matiaske F, Mommert S, Casper U, Kapp A, Weiss J
Abstract excerpt
Karyotypic and molecular data indicate that genetic alterations of the long arm of chromosome 11 (11q) are involved in the pathogenesis of malignant melanoma as well as of other malignancies. We have shown previously, by analysis of loss of heterozygosity (LOH), that a tumor-suppressor gene playi...
Topics
- Alleles
- Chromosome Deletion
- Chromosomes, Human, Pair 11
- Genes, Tumor Suppressor
- Humans
- Karyotyping
- Loss of Heterozygosity
- Melanoma
- Microsatellite Repeats
- Neoplasm Staging
- Polymerase Chain Reaction
- Polymorphism, Genetic
