Chromosomal allele loss in primary cutaneous melanoma is heterogeneous and correlates with proliferation.

doi:10.1046/j.1523-1747.1998.00109.x

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Article

Chromosomal allele loss in primary cutaneous melanoma is heterogeneous and correlates with proliferation.

The Journal of investigative dermatology - 1 Mar 1998

Böni R, Matt D, Voetmeyer A, Burg G, Zhuang Z

Abstract excerpt

Loss of heterozygosity at specific loci in neoplastic cells suggests the presence of a tumor suppressor gene within the deleted region. Using the microdissection technique, loss of heterozygosity has been identified in paraffin-embedded primary melanomas on chromosomes 1p and 9q. Our purpose was...

Topics

Alleles
Cell Division
Chromosomes
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 9
Humans
Loss of Heterozygosity
Melanoma
Polymorphism, Genetic
Skin Neoplasms

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