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Article

Loss of heterozygosity in the MXI1 gene is a frequent occurrence in melanoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2003

Ariyanayagam-Baksh Shashi M, Baksh Fabien K, Swalsky Patricia A, Finkelstein Sydney D

Abstract excerpt

Melanoma development and progression is thought to be the result of a multi-step accumulation of genetic damage, with loss of heterozygosity in chromosome 9p (MTS1) frequently described. In addition, chromosome 10q allelic loss has been reported, implicating the tumor suppressor gene PTEN/MMAC1 on 10q23.3. The MXI1 gene at 10q24-25 is another candidate tumor suppressor that has only rarely been studied in...

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Source

Identifiers

PMID: 14559981
DOI: 10.1097/01.MP.0000087421.44975.1C

Genes

MXI1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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