Loss of heterozygosity on the X chromosome in human breast cancer.

doi:10.1002/gcc.2870130402

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Article

Loss of heterozygosity on the X chromosome in human breast cancer.

Genes, chromosomes & cancer - 1 Aug 1995

Loupart M L, Adams S, Armour J A, Walker R, Brammar W, Varley J

Abstract excerpt

The analysis of loss of heterozygosity (LOH) in tumours can be a powerful tool for mapping the sites of tumour suppressor genes in the human genome. A panel of breast cancer patients was assembled as pairs of tumour and lymphocyte DNA samples and LOH studies carried out by Southern hybridisation...

Topics

Alleles
Breast Neoplasms
Chromosome Deletion
Chromosome Mapping
Female
Genetic Markers
Heterozygote
Humans
Polymorphism, Genetic
X Chromosome

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