Article
Allele losses in malignant melanoma reflect random events.
Anticancer research - 1 Jan 2000
Nordenskjöld M, Werelius B, Ringborg U
Abstract excerpt
The genetic basis for cutaneous malignant melanoma is indicated by the observations of inherited disease and the apparent correlation between exposure to mutagenic UV-light and an increased incidence of the disease. We have focused on the hypothesis that advanced disease results from gene deletions on specific chromosomes. Therefore loss of heterozygosity for polymorphic loci on all human chromosomes in a set of...
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