Retrovirus-mediated DNA repair gene transfer into xeroderma pigmentosum cells: perspectives for a gene therapy.

doi:10.1023/a:1007477820594

Back to search

Article

Retrovirus-mediated DNA repair gene transfer into xeroderma pigmentosum cells: perspectives for a gene therapy.

Cell biology and toxicology - 1 Mar 1998

Zeng L, Sarasin A, Mezzina M

Abstract excerpt

The rare hereditary disease xeroderma pigmentosum (XP) is clinically characterized by extreme sun sensitivity and an increased predisposition for developing skin cancer. Cultured cells from XP patients exhibit hypersensitivity to ultraviolet (UV) radiation due to the defect in nucleotide excision...

Topics

Animals
Cell Survival
Cells, Cultured
DNA Damage
DNA Repair
Fibroblasts
Gene Transfer Techniques
Genetic Therapy
Genetic Vectors
Humans
Mice
Phenotype
RNA
Retroviridae
Ultraviolet Rays
Xeroderma Pigmentosum

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.