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Article

Functional correction of episomal mutations with short DNA fragments and RNA-DNA oligonucleotides.

The journal of gene medicine - 1 Jan 2000

Thorpe P H, Stevenson B J, Porteous D J

Abstract excerpt

BACKGROUND: Gene correction is an alternative approach to replacement gene therapy. By correcting mutations within the genome, some of the barriers to effective gene therapy are avoided. Homologous nucleic acid sequences can correct mutations by inducing recombination or mismatch repair. Recently, encouraging data have been presented using both short DNA fragments (SDFs) and RNA-DNA oligonucleotides (RDOs) in...

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PMID: 11933220
DOI: 10.1002/jgm.249

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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