Article
Analysis of SNPs in pooled DNA: a decision theoretic model.
Genetic epidemiology - 1 Jan 2004
König Inke R, Ziegler Andreas
Abstract excerpt
Systematic analysis of the genetic background of complex diseases using single nucleotide polymorphisms (SNPs) affords a tremendous amount of genotypings. To reduce the amount of genotypings necessary and hence the overall cost of a case-control study with SNPs, the genotyping is often performed in two stages. In the first, the DNA of all cases and all controls are mixed into two pools and genotyped for each SNP....
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