Article
E-Selectin and restenosis after femoropopliteal angioplasty: prognostic impact of the Ser128Arg genotype and plasma levels.
Thrombosis and haemostasis - 1 Jan 2004
Mlekusch Wolfgang, Exner Markus, Schillinger Martin, Sabeti Schila, Mannhalter Christine, Minar Erich, Wagner Oswald
Abstract excerpt
Perivascular inflammation plays a key role in the development of restenosis after percutaneous transluminal angioplasty (PTA). The adherence of leucocytes to the activated endothelium, an essential feature in the restenotic process, is mediated by the cellular adhesion molecule E-Selectin. A DNA polymorphism in the regulator region of E-Selectin at codon 561 (Ser128Arg) is suggested to modulate the molecule's...
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