Article
Homozygosity in the single nucleotide polymorphism Ser128Arg in the E-selectin gene associated with recurrent venous thromboembolism.
Archives of internal medicine - 1 Jan 2000
Jilma Bernd, Kovar Florian M, Hron Gregor, Endler Georg, Marsik Claudia L, Eichinger Sabine, Kyrle Paul A
Abstract excerpt
BACKGROUND: The single nucleotide polymorphism (SNP) Ser128Arg in the E-selectin gene is overrepresented in certain patient populations with atherosclerosis or restenosis. As this SNP enhances tissue factor-triggered coagulation in humans during systemic inflammation, we hypothesized that it may...
Topics
- Adult
- Arginine
- E-Selectin
- Female
- Homozygote
- Humans
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Recurrence
- Serine
- Thromboembolism
- Venous Thrombosis