Article
An HphI polymorphism in the E-selectin gene is associated with premature coronary artery disease.
Clinical genetics - 1 Jan 2001
Zheng F, Chevalier J A, Zhang L Q, Virgil D, Ye S Q, Kwiterovich P O
Abstract excerpt
An increased expression of E-selectin has been observed in the arterial endothelium interacting with lymphocytes and macrophages in human atherosclerotic lesions. We examined whether a polymorphism in the E-selectin gene, due to a G to T mutation (G98T) in the untranslated region of exon 2, was associated with premature coronary artery disease (CAD). Other lipid and nonlipid risk factors including a Ser to Arg...
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