Article
Functional characterization of atherosclerosis-associated Ser128Arg and Leu554Phe E-selectin mutations.
Biological chemistry - 1 Jun 1999
Wenzel K, Stahn R, Speer A, Denner K, Gläser C, Affeldt M, Moobed M, Scheer A, Baumann G, Felix S B
Abstract excerpt
The cellular adhesion molecule E-selectin is expressed on activated endothelial cells, and is involved in the process of adherence of blood cells to vessel endothelium in inflammatory events such as atherosclerosis. In a recent study we found a Ser128Arg mutation in the EGF domain as well as a Leu554Phe mutation in the membrane domain of E-selectin. We also established increased frequencies of both mutations...
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