Article
A common variant of endothelial nitric oxide synthase (Glu298Asp) is associated with collateral development in patients with chronic coronary occlusions.
BMC cardiovascular disorders - 15 Sept 2005
Lamblin Nicolas, Cuilleret François J, Helbecque Nicole, Dallongeville Jean, Lablanche Jean-Marc, Amouyel Philippe, Bauters Christophe, Van Belle Eric
Abstract excerpt
BACKGROUND: Experimental studies support an important role for endothelial nitric oxide synthase (eNOS) in the regulation of angiogenesis. In humans, a common polymorphism exists in the eNOS gene that results in the conversion of glutamate to aspartate for codon 298. In vitro and in vivo studies have suggested a decreased NOS activity in patients with the Asp298 variant. We hypothesized that a genetic-mediated...
Topics
- Chronic Disease
- Collateral Circulation
- Coronary Disease
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Multivariate Analysis
- Nitric Oxide Synthase Type III
- Polymorphism, Genetic
- Sex Factors
- Smoking