Article
Constitutively active mutants of MAP kinase kinase (MEK1) induce growth factor-relaxation and oncogenicity when expressed in fibroblasts.
Oncogene - 1 Nov 1994
Brunet A, Pagès G, Pouysségur J
Abstract excerpt
The Mitogen Activated Protein Kinase (MAPK) module operates downstream of Ras to convey cell surface signals to the nucleus via the nuclear translocation of p42/p44 MAPKs. We have previously established that MAPK activation is obligatory and must persist in the G1 phase to allow resting fibroblas...
Topics
- Animals
- Cell Transformation, Neoplastic
- Cells, Cultured
- Cricetinae
- Cricetulus
- Fibroblasts
- Growth Substances
- Lung
- MAP Kinase Kinase 1
- MAP Kinase Kinase Kinases
- Mice
- Mice, Nude
- Mitogen-Activated Protein Kinase Kinases
- Mutation
- Protein Kinases
- Protein Serine-Threonine Kinases
- Protein-Tyrosine Kinases
- Recombinant Proteins