Article
Identification of neurofibromin mutants that exhibit allele specificity or increased Ras affinity resulting in suppression of activated ras alleles.
Molecular and cellular biology - 1 May 1996
Morcos P, Thapar N, Tusneem N, Stacey D, Tamanoi F
Abstract excerpt
Neurofibromin plays a critical role in the downregulation of Ras proteins in neurons and Schwann cells. Thus, the ability of neurofibromin to interact with Ras is crucial for its function, as mutations in NF1 that abolish this interaction fail to maintain function. To investigate the neurofibromi...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Cloning, Molecular
- DNA Primers
- Escherichia coli
- GTPase-Activating Proteins
- Gene Library
- Genes, ras
- Humans
- Kinetics
- Mammals
- Molecular Sequence Data
- Mutagenesis, Site-Directed