Article
Transformation of mammalian cells by constitutively active MAP kinase kinase.
Science (New York, N.Y.) - 12 Aug 1994
Mansour S J, Matten W T, Hermann A S, Candia J M, Rong S, Fukasawa K, Vande Woude G F, Ahn N G
Abstract excerpt
Mitogen-activated protein (MAP) kinase kinase (MAPKK) activates MAP kinase in a signal transduction pathway that mediates cellular responses to growth and differentiation factors. Oncogenes such as ras, src, raf, and mos have been proposed to transform cells by prolonging the activated state of M...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Enzyme Activation
- Genes, mos
- Mice
- Mitogen-Activated Protein Kinase 1
- Mitogen-Activated Protein Kinase Kinases
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein Kinases
- Protein Serine-Threonine Kinases
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins c-jun