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Article

Transformation of mammalian cells by constitutively active MAP kinase kinase.

Science (New York, N.Y.) - 12 Aug 1994

Mansour S J, Matten W T, Hermann A S, Candia J M, Rong S, Fukasawa K, Vande Woude G F, Ahn N G

Abstract excerpt

Mitogen-activated protein (MAP) kinase kinase (MAPKK) activates MAP kinase in a signal transduction pathway that mediates cellular responses to growth and differentiation factors. Oncogenes such as ras, src, raf, and mos have been proposed to transform cells by prolonging the activated state of MAPKK and of components downstream in the signaling pathway. To test this hypothesis, constitutively active MAPKK...

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PMID: 8052857
DOI: 10.1126/science.8052857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Transformation of mammalian cells by constitutively active MAP kinase kinase.PMID 8052857Read ↗

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