Article
A recessive mutant cell line with a constitutive IkappaB kinase activity.
FEBS letters - 20 Nov 2002
Chinanonwait Netnaphis, Miura Hideyasu, Yamamoto Naoki, Yamaoka Shoji
Abstract excerpt
To search for negative regulatory components of the NF-kappaB activation pathways, we mutagenized Rat-1 fibroblasts and established a stable mutant cell line with a constitutive NF-kappaB activity. This mutant cell line, designated as TK26, showed permanently elevated I kappa B kinase (IKK) activity and a genetically recessive phenotype revealed by somatic cell hybridization between TK26 and Rat-1. Our results...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.