Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression profiling of Dexamethasone-treated primary chondrocytes identifies targets of glucocorticoid signalling in endochondral bone development

1 Jul 2007

Abstract excerpt

BACKGROUND: Glucocorticoids (GCs) are widely used anti-inflammatory drugs. While useful in clinical practice, patients taking GCs often suffer from skeletal side effects including growth retardation in children and adolescents, and decreased bone quality in adults. On a physiological level, GCs have been implicated in the regulation of chondrogenesis and osteoblast differentiation, as well as maintaining...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone health and osteoporosis research
Share to Growth Hormone and Insulin-like Growth Factors
Share to Osteoarthritis Treatment and Mechanisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17603917
DOI: 10.1186/1471-2164-8-205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression profiling of Dexamethasone-treated primary chondrocytes identifies targets of glucocorticoid signalling in endochondral bone developmentPMID 17603917Read ↗

Widespread regulation of gene expression by glucocorticoids in chondrocytes from patients with osteoarthritis as determined by RNA-SeqSemantic proximity Read ↗

Gene expression analysis in human osteoblasts exposed to dexamethasone identifies altered developmental pathways as putative drivers of osteoporosisSemantic proximity Read ↗

Short and Long-Term Effect of Dexamethasone on the Transcriptome Profile of Primary Human Trabecular Meshwork Cells In vitroSemantic proximity Read ↗

Glucocorticoids promote development of the osteoblast phenotype by selectively modulating expression of cell growth and differentiation associated genes.Semantic proximity Read ↗

A Comparative Genome-wide Transcriptome Analysis of Glucocorticoid Responder and Non-Responder Primary Human Trabecular Meshwork CellsSemantic proximity Read ↗

Modulation of ossification and inflammatory pathways during dexamethasone-induced <i>in vitro</i> osteogenesisSemantic proximity Read ↗

Minireview: Live and Let Die: Molecular Effects of Glucocorticoids on Bone CellsSemantic proximity Read ↗

Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genesSemantic proximity Read ↗

A Comparative Genome-Wide Transcriptome Analysis of Glucocorticoid Responder and Non-Responder Primary Human Trabecular Meshwork CellsSemantic proximity Read ↗

Gene expression profiling of glucocorticoid-inhibited osteoblastsSemantic proximity Read ↗

Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cellsSemantic proximity Read ↗

Molecular analysis of expansion, differentiation, and growth factor treatment of human chondrocytes identifies differentiation markers and growth-related genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.