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Article

Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 2004

Reiman Eric M, Chen Kewei, Alexander Gene E, Caselli Richard J, Bandy Daniel, Osborne David, Saunders Ann M, Hardy John

Abstract excerpt

Fluorodeoxyglucose positron emission tomography (PET) studies have found that patients with Alzheimer's dementia (AD) have abnormally low rates of cerebral glucose metabolism in posterior cingulate, parietal, temporal, and prefrontal cortex. We previously found that cognitively normal, late-middle-aged carriers of the apolipoprotein E epsilon4 allele, a common susceptibility gene for late-onset Alzheimer's...

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Identifiers

PMID: 14688411
DOI: 10.1073/pnas.2635903100
PMCID: PMC314177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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