Article
Lack of association of apolipoprotein E epsilon4 allele dose with cerebral glucose metabolism in Alzheimer disease.
Alzheimer disease and associated disorders - 1 Dec 1998
Hirono N, Mori E, Yasuda M, Ishii K, Ikejiri Y, Imamura T, Shimomura T, Hashimoto M, Yamashita H, Sasaki M
Abstract excerpt
Parietal cerebral glucose metabolism is reduced before substantial impairments appeared in subjects carrying the apolipoprotein E (APOE) epsilon4 allele, but the effect of the APOE epsilon4 allele on cerebral metabolism in Alzheimer disease (AD) is still undetermined. To investigate the effect of...
Topics
- Aged
- Alleles
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Blood Glucose
- Brain
- Brain Mapping
- Energy Metabolism
- Female
- Fluorodeoxyglucose F18
- Genotype
- Humans
- Male
- Middle Aged
- Sensitivity and Specificity
- Tomography, Emission-Computed