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Article

Hypometabolism in Alzheimer-affected brain regions in cognitively healthy Latino individuals carrying the apolipoprotein E epsilon4 allele.

Archives of neurology - 1 Apr 2010

Langbaum Jessica B S, Chen Kewei, Caselli Richard J, Lee Wendy, Reschke Cole, Bandy Daniel, Alexander Gene E, Burns Christine M, Kaszniak Alfred W, Reeder Stephanie A, Corneveaux Jason J, Allen April N, Pruzin Jeremy, Huentelman Matthew J, Fleisher Adam S, Reiman Eric M

Abstract excerpt

OBJECTIVE: To investigate with fluorodeoxyglucose positron emission tomography whether regional reductions in the cerebral metabolic rate for glucose (CMRgl) previously found in cognitively healthy late-middle-aged apolipoprotein E (APOE) epsilon4 carriers extend to members of the Latino Mexican American community. DESIGN: Prospective cohort study. SETTING: Banner Alzheimer's Institute, Phoenix, Arizona. PATIENTS...

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Identifiers

PMID: 20385913
DOI: 10.1001/archneurol.2010.30
PMCID: PMC2943432

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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