Article
Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease.
JAMA - 1 Jan 2000
Small G W, Mazziotta J C, Collins M T, Baxter L R, Phelps M E, Mandelkern M A, Kaplan A, La Rue A, Adamson C F, Chang L
Abstract excerpt
OBJECTIVE: Cerebral parietal hypometabolism and left-right asymmetry occur early in the course of Alzheimer disease (AD), and the apolipoprotein E type 4 allele (APOE epsilon 4) is a risk factor for familial AD. To determine if APOE epsilon 4 is associated with lowered brain function in nondement...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Analysis of Variance
- Apolipoprotein E4
- Apolipoproteins E
- Brain
- Deoxyglucose
- Family
- Female
- Fluorine Radioisotopes
- Fluorodeoxyglucose F18
- Genotype
- Glucose
- Humans
- Magnetic Resonance Imaging