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Article

Structural determinants regulating expression of the high affinity leukotriene B4 receptor: involvement of dileucine motifs and alpha-helix VIII.

The Journal of biological chemistry - 12 Mar 2004

Gaudreau Rémi, Beaulieu Marie-Eve, Chen Zhangguo, Le Gouill Christian, Lavigne Pierre, Stanková Jana, Rola-Pleszczynski Marek

Abstract excerpt

Mutational analysis of determinants located in the C-terminal (C) tail of the high affinity leukotriene (LT) B(4) receptor, BLT1, was performed to assess their significance in BLT1 trafficking. When expressed in COS-7 cells, a BLT1 deletion mutant lacking the C-tail (G291stop) displayed higher numbers of binding sites and increased signal transduction compared with wild-type (WT) BLT1. Addition of the C-tail from...

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PMID: 14688279
DOI: 10.1074/jbc.M309207200

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LTB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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