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Article

Helix 8 of the leukotriene B4 receptor is required for the conformational change to the low affinity state after G-protein activation.

The Journal of biological chemistry - 17 Oct 2003

Okuno Toshiaki, Ago Hideo, Terawaki Kan, Miyano Masashi, Shimizu Takao, Yokomizo Takehiko

Abstract excerpt

Recent studies have revealed that G-protein-coupled receptors contain a putative cytoplasmic helical domain, helix 8. Leukotriene B4 (LTB4) receptor 1 derivatives with truncated or mutated helix 8 showed much higher LTB4 binding than wild-type (WT) receptors. Similar to the WT receptor, LTB4 promoted guanosine 5'-3-O-(thio)triphosphate (GTPgammaS) binding in these mutants. Unlike the WT receptor, however, the...

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PMID: 12902330
DOI: 10.1074/jbc.M307335200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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