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Article

Phosphorylation-independent beta-arrestin translocation and internalization of leukotriene B4 receptors.

The Journal of biological chemistry - 11 Feb 2005

Jala Venkatakrishna R, Shao Wen-Hai, Haribabu Bodduluri

Abstract excerpt

Leukotriene B4 (LTB4) activates the G-protein-coupled receptor leukotriene B4 receptor 1 (BLT1) to mediate a diverse array of cellular responses in leukocytes including chemotaxis, calcium mobilization, degranulation, and gene expression. To determine the role of phosphorylation in BLT1 regulation, we generated mutants of BLT1 in which all of the serine/threonine residues in the C-tail are converted to alanine or...

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PMID: 15561704
DOI: 10.1074/jbc.M409821200

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