Article
A conserved motif for the transport of G protein-coupled receptors from the endoplasmic reticulum to the cell surface.
The Journal of biological chemistry - 16 Jul 2004
Duvernay Matthew T, Zhou Fuguo, Wu Guangyu
Abstract excerpt
The structural determinants for the export trafficking of G protein-coupled receptors are poorly defined. In this report, we determined the role of carboxyl termini (CTs) of alpha2B-adrenergic receptor (AR) and angiotensin II type 1A receptor (AT1R) in their transport from the endoplasmic reticulum (ER) to the cell surface. The alpha2B-AR and AT1R mutants lacking the CTs were completely unable to transport to the...
Topics
- Alanine
- Amino Acid Motifs
- Amino Acid Sequence
- Animals
- Cell Line
- Cell Membrane
- Dose-Response Relationship, Drug
- Endoplasmic Reticulum
- Flow Cytometry
- Humans
- Immunoblotting
- Isoleucine
- Leucine
- Ligands